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Development of Crystallization Processes

Course Outline:

1. Introduction to Process Synthesis and Development

  • Goals of process synthesis and development 

  • Approaches 

  • Challenges in developing crystallization-based processes 

2. SLE Phase Diagrams

  • Basic concepts 

  • Types of phase diagrams: Organic systems, ionic systems 

3. Synthesis of Crystallization-Based Processes

  • Traditional crystallization separation techniques: Fractional crystallization, drowning-out crystallization

  • Unified approach: Basic movements in composition space, examples 

4. Mass Transfer and Kinetic Effects

  • Effect on crystallization paths 

  • Crystallization operating policy: Programmed cooling, antisolvent addition, seeding 

5. Design Issues Related to the Process, Crystallizer and Solid-Liquid Separation

  • Practical issues related to crystallizer operations 

  • Scale-up of crystallizers: Mixing, particle handling 

  • Design of crystallization downstream solid-liquid separation system

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Consortium of Chemical Products and Processes
Department of Chemical Engineering
Hong Kong University of Science and Technology
Clear Water Bay, Kowloon, Hong Kong