Dr. Jun XIA (Ph.D., Johns Hopkins, 2001)

Research Interests

Molecular mechanism of protein trafficking and its implication in brain disorder, diabetes and infertility.

Molecular and cellular bases of learning and memory, organization of synapse and regulation of synaptic transmission.

Representative Publications

1. Xu, J., Xiao, N., Xia, J. (2009). Thrombospondin 1 Accelerates Synaptogenesis in Hippocampal Neurons through Neuroligin 1. Nat. Neurosci. In press.
2. Xiao, N., Kam, C., Shen, C., Jin, W., Wang, J., Lee, K.M., Jiang, L., and Xia, J. (2009). PICK1 deficiency causes male infertility in mice by disrupting acrosome formation. J. Clin. Invest. 119(4): 802-812.
3. Cao, M., Xu, J., Shen, C., Kam, C., Huganir, R.L., and Xia, J. (2007). PICK1-ICA69 heteromeric BAR domain complex regulates synaptic targeting and surface expression of AMPA receptors. J. Neurosci. 27(45): 12945-12956.
4. Pan, L., Wu, H., Shen, C., Shi, Y., Jin, W., Xia, J.,* and Zhang, M.* (2007). Clustering and synaptic targeting of PICK1 requires direct interaction between the PDZ domain and lipid membranes. EMBO J. 26(21): 4576-87. * Co-corresponding authors.
5. Jin, W., Ge, W., Xu, J., Cao, M., Peng, L., Yung, W., Liao, D., Duan, S., Zhang, M., and Xia, J. (2006). Lipid binding regulates PICK1’s synaptic targeting, AMPA receptor trafficking and synaptic plasticity. J. Neurosci. 26(9): 2380-2390.
6. Steinberg, J.P., Takamiya, K., Shen, Y., Xia, J., Rubio, M.E., Yu, S., Jin, W., Thomas, G.M., Linden, D.J., and Huganir, R.L. (2006). Targeted in vivo mutations of the AMPA receptor subunit GluR2 and its interacting protein PICK1Eliminate Cerebellar long-term depression. Neuron 49(6): 845-860.
7. Gardner, S.M., Takamiya, K., Xia, J., Suh, J., Johnson, R., Yu, S., and Huganir, R.L. (2005). Calcium-Permeable AMPA receptor plasticity is mediated by subunit-specific interactions with PICK1 and NSF. Neuron 45(6): 903-915.
8. Long, J.F., Feng, W., Wang, R., Chan, L.N., Ip, F.C., Xia, J., Ip, N.Y., and Zhang, M. (2005). Autoinhibition of X11/Mint scaffold proteins revealed by the closed conformation of the PDZ tandem. Nat. Struct. Mol. Biol. 12(8): 722-8.
9. Xia, J., Chung, H.J., Wihler, C., Huganir, R.L., and Linden, D.J. (2000). Cerebellar long-term depression requires PKC regulated interactions between GluR2/3 and PDZ domain-containing proteins. Neuron. 28(2): 499-510.
10. Xia, J., Zhang, X., Staudinger, J., and Huganir, R.L. (1999). Clustering of AMPA receptors by the synaptic PDZ domain-containing protein PICK1. Neuron. 22(1): 179-87.