Research
Faculty Research Interests & Areas Biotechnology Research Institute Molecular Neuroscience Center
Faculty Index
Home » Research » Faculty Research Interests & Areas » Guang ZHU

Dr. Guang Zhu (Ph.D., Maryland, 1992)

 

 

Associate Professor

Email: gzhu@ust.hk

Research Interests

Development and Improvement of Multidimensional NMR data processing procedures and experimental techniques. Structure and function study of macrobiomolecules by NMR.

Representative Publications

 

  1. Jing WANG, Changdong LIU, Bo ZHOU, David K. SMITH and Guang ZHU* (2008) The SWIRM Domain of LSD1 interacts with the N-terminal Tail of Histone H3, submitted to J Biochem. And Cell Biol.
  2. Yinliang Yin, Vivian C. Yu, Guang ZHU* and Donald C. Chang*(2008) SET8 plays a role in controlling G1/S transition by blocking lysine acetylation in histone through binding to H4 N-terminus tail, Cell Cycle 7 (10) 1423-1432.
  3. Bo ZHOU, Lihong CHEN, Xing WU, Jing WANG, Yinliang YIN and Guang ZHU*(2008) MH1 Domain of SMAD4 Binds N-terminal Residues of the Homeodomain of Hoxc9, BBA-Proteins&Proteomics 1784(5):747-52.
  4. Guang ZHU* and Xuejun YAO (2008) TROSY-based NMR experiments for large biomolecules, Prog. in NMR Spectroscopy. 52 49-68.
  5. 姚雪筠，朱广（2008）运用预饱和对HOESY实验灵敏度优化, Chinese Journal of Magnetic resonance. In press.
  6. Denise S.B. Chan, Lai-On Chu, Ka-Ming Lee, Priscilla H.M. Too, Kit-Wan Ma, Kong-Hung Sze, Guang ZHU, Pang-Chui Shaw and Kam-Bo Wong（2007）Interaction between trichosanthin, a ribosome-inactivating protein, and the ribosomal stalk protein P2 by chemical shift perturbation and mutagenesis analyses。Nucleic Acids Research, 35, 1660-72.
  7. Yin, Y. L., G. ZHU*(2006) SET8 recognizes the sequence RHRKB20BVLRDN within the N-terminus of histone H4 and mono-methylates lysine 20. Neurosignals 15, 52.
  8. Yinlian YIN , Changdong LIU, Helen TSAI, Bo ZHOU, Sai Ming NGAI, Guang ZHU* (2005) SET8 Recognizes the Sequence RHRK20VLRD within the N-terminus of Histone H4 and Mono-methylates Lysine 20, J. Biol Chem 280, 30025-31.
  9. Kewei Ma, Jonathan K.L.Chan, Guang ZHU, and Zhenguo Wu (2005) Myocyte Enhancer Factor 2 Acetylation by p300 Enhances Its DNA Binding Activity, Transcription Activity, and Myogenic Differentiation, Mol. And Cell. Biol, 3575-3582 
  10. Guang ZHU*, Youlin Xia, Donghai Lin, and Xiaolian Gao, (2004) TROSY-based NMR experiments for the study of macromolecular dynamics and hydrogen bonding, (Chapter 11, Methods in Molecular Biology/Molecular Medicine, Humana Press), 161-184
  11. Guang ZHU*, Youlin Xia, Donghai Lin, and Xiaolian Gao(2004) TROSY based correlation and NOE spectroscopy for NMR structural studies of large proteins (Chapter 5, Methods in Molecular Biology/Molecular Medicine, Humana Press) 57-78
  12. Youlin Xia, Guang Zhu and Xiaolian Gao (2004) (3,2)D GFT-NMR Experiments for Fast Collection of Protein Data J. Biomol. NMR, 29 (4): 467-476
  13. Yong-Neng Yao, Qing-Shuo Zhang, Xian-Zhong Yan, Guang ZHU, and En-do Wang (2004) “E. Coli tRNA4Arg (UCU) induces a constrained conformation the crucial W-loop of arginyl-tRNA synthetase” Biochemical and Biophysical Research Communications 313 129-134.
  14. H. Chen, Richard K. Haynes, Jürgen Scherkenbeck, Kong H. Sze and Guang Zhu (2004) Elucidation of Solution Conformations of Loloatin C by NMR Spectroscopy Combined with Molecular Simulation, European Journal of Organic Chemistry 31-37.
  15. Radivojac P, Obradovic Z, Smith DK, Zhu G, Vucetic S, Brown CJ, Lawson JD, Dunker AK (2004) “Protein flexibility and intrinsic disorder” Protein Science 2004 13(1):71-80.
  16. Yong-Neng Yao, Qing-Shuo Zhang, Xian-Zhong Yan, Guang ZHU*, En-Duo Wang* (2003) Substrate-Induced Conformational Changes in Escherichia coli Arginyl-tRNA Synthetase Observed by 19F NMR spectroscopy, FEBS Letter 547 197-200.
  17. Jonathan K.L. Chan, Luguo Sun, Xiang-jiao Yang, G. ZHU, and Zhenguo Wu3 (2003) Functional characterization of an amino terminal region of HDAC4 that
    possesses MEF2 binding and transcriptional repressive activity, J. Biol. Chem. 278 (26): 23515-23521.
  18. Yanfang Cui, Jian Wen, Konghung Sze, David Man2, Donghai Lin, Maili Liu, and Guang ZHU* (2003) “Interaction Studies Between Calcium-free Calmodulin and the IQ Motif of Neurogranin Using NMR Spectroscopy” Analytical Biochemistry Apr 15;315(2):175-82.
  19. D. K. Smith, P. Radivojac, Z. Obradovic, A. K. Dunker and G. ZHU* (2003) “Improved Amino Acid Flexibility Parameters”, Protein Science 12(5):1060-1072.
  20. Guang ZHU* (2002) Multidimensional NMR data processing, (Chapter 17, Signal processing for magnetic resonance imaging and spectroscopy. Edited by Hong Yan, PP509-543 Marcel Dekker, Inc, New York).
  21. Ya-Hui CHI, Thallampuranam Krishnaswamy S. KUMAR, Dong-Hai LIN, Guang ZHU, Ing-Ming Chiu and Chin Yu(2002) “Investigation of the Structural Stability of the Human Acidic Fibroblast Growth Factor by Hydrogen-Deuterium Exchange” Biochemistry. 41, 15350-9.
  22. Qing Guo, Qingguo Gong, Ka-Lok Tong, Bente Vestergaard, Annie Costa, Jean Desgres, Mansim Wong3, Henri Grosjean, Guang Zhu, J. Tze-Fei Wong3, and Hong Xue3 (2002) Recognition by Tryptophanyl-tRNA Synthetases of Discriminator Base on tRNATrp from Three Biological Domains. J. Biol. Chem. 277: 14343-14349.
  23. Donghai LIN, Kong Hung SZE, Yanfan CUI and Guang ZHU* (2002) Clean sea-HSQC: a method to Map Solvent Exposed Amides in Large Proteins with Gradient-enhanced HSQC, J. Biomol. NMR 23, 317-322.
  24. Qingguo GONG Qing GUO, Guang ZHU, J.F. WONG and Hong XUE (2002) NMR Analysis of Bovine tRNATrp: Conformation Dependence of Mg2+ Binding Sites, J Biol Chem. 277 20694-20701.
  25. Youlin XIA, KONG Hung SZE, N. Li, P.C. ShAW and Guang ZHU* (2002) Protein Dynamics Measurements by 3D HNCO Based NMR Experiments, Spectroscopy, an international journal,16, 1-13.
  26. Wei He, Ke Gong, Guang Zhu, David Smith, Nancy IP, (2002) Memberane distal cytokine binding domain of LIFR interacts with the soluble CNTFR in Vitro, FEBS Letter 514 214-218.
  27. David Man, Youlin XIA, Kong H. SZE, David K. SMITH, Wei HE, Nancy Y. IP and Guang ZHU* (2002) Complete 1H, 15N and 13C assignments of the carboxyl terminal domain of the ciliary ceurotrophic factor receptor (CNTFR), J. Biomol. NMR, 22 95-96
  28. Youlin XIA, D. MAN, and Guang ZHU* (2001) “3D Haro-NOESY-CH3NH and Caro-NOESY-CH3NH Experiments for Double Labeled Proteins” J. Biomol. NMR 19, 355-360.
  29. Bingwen LU, Laikwan PEI, Waikin CHAN, Hong ZHANG, Guang ZHU, Jiayang LI and Ning LI (2001) “The dual effects of ethylene on the negative gravicurvature of arabidopsis inflorescence, an intriguing action model for the plant hormone ethylene”, Chinese Science Bulletin 46, 1.
  30. Youlin XIA, Kong Hong SZE and Guang ZHU* (2000) Transverse Relaxation optimized 3D and 4D 15N/15N separated NOESY 15N labeled of Protein labeled. J.Biomol. NMR 18, 261-268.
  31. Xianzhong YAN, Xiangming KONG, Youlin XIA, Konghung SZE and Guang ZHU*, (2000) Determination of Internucleotide hJHN Couplings by the Modified 2D JNN Correlated-[15N, 1H]-TROSY, J. Magn. Reson. 147, 357-360.
  32. Youlin XIA, Xiangming KONG, Nancy IP and Guang ZHU* (2000) A J-Multiplied HMQC (MJ-HMQC) Experiment for Measuring 3JHNHa Coupling Constants, J. Magn. Reson. 146, 228-231.
  33. Youlin XIA Xiangming KONG, Yu LIU, David MAN, David SMITH and Guang ZHU* (2000) Sensitivity Enhancement of HCACO by Using an HMQC Magnetization Transfer Scheme. J. Mang. Reson. 143,407-410.
  34. Qingwen ZHANG, Wencai YE, Xiangzhong YAN, Guang ZHU, Chuntao CHE and Shouxun ZHAO3 (2000) Sucrase Inhibitory Sanonins from Pulsatilla Cernua J. Nat. Prod. 63, 276-278.
  35. Guang ZHU*, Youlin XIA, Linda Nicholson, and Kong Hung SZE (2000). TROSY-Based NMR dynamics study of proteins labeled with 15N. J. Magn. Reson. 143,423-426.
  36. Xianzhong YAN, Hong XUE, Hongzhi LIU, Jun HANG, J. Tze-Fei WONG and Guang ZHU* (2000) NMR Studies of Bacillus subtilis tRNATrp Hyper-expressed in E.coli: Assignment of Imino Proton Signals and Determination of Thermal Stability J. Biol. Chem. 275, 6712-6716.
  37. Guang ZHU*, Youlin XIA, Konghong SZE and Xianzhong YAN (1999). 2D and 3D TROSY Enhanced NOESY of 15N Labeled Proteins. J. Biom. NMR, 14, 377-381.
  38. Konghong SZE, Xiangming KONG and Guang ZHU* (1999). Measuring 3JCH by 3D J-Resolved HMBC Experiment. Tetrahedron lett. 40, 5587-5591.
  39. Xiangming KONG, Konghong SZE, and Guang ZHU*(1999). Gradient and Sensitivity Enhanced Multiple-quantum Coherence and Its Application in Heteronuclear Multi-dimensional NMR Experiments. J. Biomol. NMR, 14, 133-140.
  40. Guang ZHU*, Xiangming KONG and Konghong SZE. (1999). Gradient and sensitivity enhancement of 2D TROSY with water flip-back, 3D NOESY-TROSY and TOCSY-TROSY experiments J. Biomol. NMR, 13 (1): 77-81.
  41. Guang ZHU*, Xiangming KONG, Xianzhong YAN, and Konghong SZE (1998) Sensitivity Enhancement of Transverse Relaxation-optimized Spectroscopy. Angew. Chem. Int. Ed. Engl. 37, 2859-2861. (it was selected as a “hot” paper)
  42. Guang ZHU*, Xiangming KONG, and Konghong SZE, (1998), Gradient and Sensitivity Enhanced HMQC experiment. J. Magn. Reson. 135, 232-235.
  43. Guang ZHU*, Wingyiu CHOY, B.C. Sanctuary, and Guoqiang SONG, (1998), Suppression of Diagonal peaks by Singular Value Decomposition. J.Magn.Reson. 132 176-178.
  44. Wingyiu CHOY, B.C. Sanctuary and Guang ZHU*, (1997), Using Neural Network Predicted Secondary Structure and Information in Automatic Protein NMR Assignment. J. Chem. Info. Comp. Sci. 37, 1086-1094.
  45. Guang ZHU*, David SMITH and Yinbo HUA, (1997).Post-Acquisition Solvent Suppression By Singular Value Decomposition. J. Magn. Reson 124, 286-290.
  46. Guang Zhu*, and Yinbo HUA, (1997) Quantitative NMR spectral analysis by an interative maximum likelihood method. Chem. Phys. Lett 264, 424-429.
  47. Guang ZHU*, (1996).Application of a Three-Dimensional Maximum Entropy Method to Processing Sections of Three-Dimensional NMR Spectra. J Magn Reson Series B 113, 248-251.
  48. Frank Delaglio, Stephen Greziesk, Geerten Vuister, Guang Zhu, Johon Pfeifer and Ad Bax. (1995). NMRPipe: A multidimensional spectral processing system based on Unix pipes. J. Biomol. NMR, 6 277-293.
  49. Guang Zhu, David Live and Ad Bax, (1994). “Stable Isotope Applications in Biomolecular Structure and Mechanisms”, (edited by J. Trewhella, T.A. Cross and C. J. Unkefer), Los Alamos, New Mexico, pp345,.
  50. Guang Zhu, Alistair Renwick, and Ad Bax. (1994). Measurement of two- and three-bond 1H-13C J couplings from quantitative heteronuclear J correlation for molecules with overlapping 1H resonances, Using T1 Noise Reduction. J. Magn. Reson Series A 110, 257-261.
  51. Guang Zhu, David Live and Ad Bax. (1994). Analysis of Sugar Puckers and Glycosidic Torsion Angles in a DNA G-Tetrad Structure by Heteronuclear Three-Bond J Couplings. J. Am. Chem Soc.116, 8370-71.
  52. Ad Bax, Geerten W. Vuister, Stephan Grzesiek, Frank Delaglio, Andy C. Wang, Rolf Tschudin, and Guang Zhu. (1994).Measurement of homo- and heteronuclear J couplings from quantitative J correlation. Methods in Enzymology Vol. 239,79-105.
  53. Guang Zhu, Denis Torchia and Ad Bax. (1993).Discrete Fourier Transformation of NMR Signals. The Relationship between Sampling Delay Time and Spectral Baseline. J. Magn.Reson. Series A 105, 219-222.
  54. Guang Zhu and Ad Bax. (1993). Quantitative Measurement of Long-range 1H-13C J Couplings from Proton Detected HMBC Spectra. J. Magn. Reson. Series A 104, 353-357.
  55. Guang Zhu and Ad Bax. (1992). Improved Linear Prediction of Truncated Damped Sinusoids Using modified Backward-Forward Linear Prediction. J. Magn. Reson. 100, 202-207.
  56. Guang Zhu and Ad Bax. (1992). Two-dimensional Linear Prediction for Signals Truncated in Both Dimensions. J. Magn. Reson. 98, 192-199.
  57. M. Ikura, G.M. Clore, A.M. Gronenborn, Guang Zhu, C.B. Klee, and A. Bax, (1992) Solution Structure of a Calmodulin-Target Peptide Complex by Multidimensional NMR. Science, 256, 632-638.
  58. Ad Bax, Mitsuhiko Ikura, Lewis E. Kay and Guang Zhu, (1991). Removal of F1 Baseline Distortion and Optimization of Folding in Multi-Dimensional NMR Spectra. J. Magn. Reson. 91,174-178.
  59. Lewis E. Kay, Mitsuhiko Ikura, Guang Zhu and Ad Bax, (1991). Four-Dimensional Heteronuclear Triple Resonance NMR of Isotopically Enriched Proteins for Sequential assignment of Backbone atoms. J. Magn. Reson.91,422-428.
  60. Lewis E. Kay, Mitsuhiko Ikura, Guang Zhu and Ad Bax, (1991). “3-Dimensional and 4-Dimensional Heteronuclear Triple Resonance NMR Spectroscopy of Proteins in Solution.” Abstracts of Paper of the American Chemical society. 201, APR. 74.
  61. Guang Zhu and Ad Bax, (1990) Improved Linear Prediction for Truncated Signals of Known Phase. J. Magn. Reson. 90,405-410.
  62. M.L. Rustgi, L.N. Pandey, J.W. Wilson, S.A.T. Long and Guang Zhu, (1988) Distribution of Energy in Polymers Due to Incident Electrons and Protons. Radiation Effec. and Defec. in Solids 105 3-4 30.

 
 
Copyright@2006. All rights reserved. Created by Wei Heng; Last updated on March 25, 2006.